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View full-text article in PMC

. 2019 Nov 8;116(48):24115–24121. doi: 10.1073/pnas.1913905116

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Fig. 2. — Cardiac arrhythmia and prolonged atrial depolarization in pitx2c^−/− adult hearts. Electrical conduction properties of 8-month postfertilization (mpf) adult hearts by ECG analysis. Representative ECG traces and Poincaré plots of consecutive RR intervals from pitx2c^+/+ (A), pitx2c^+/− (B), and pitx2c^−/− (C) hearts. Individual fish are each represented by a differently colored line. Quantification of heart rate (D), RR interval (E), P-wave duration (F), PR interval (G), QT interval (H), and QRS interval (I). pitx2c^+/− and pitx2c^−/− fish exhibit a variable and lower heart rate (B–E) and disrupted atrial conduction (F and G), while the ventricular conduction system seems unaffected (H and I). Error bars correspond to SEM. *P < 0.05 by 1-way ANOVA; **P < 0.01 by 1-way ANOVA.