Fig. 3.

Human-specific genes are enriched for cognitive disease risk variants. (A and B) Bar plots highlighting the enrichment for genetic variants [−log₁₀(FDR)]. Bars correspond to (A) NeuN modules (NM19: tan, NM21: yellow) and (B) OLIG2 modules (OM2: blue, OM15: turquoise) species-specific modules (***FDR < 0.001, **FDR < 0.01, *FDR < 0.05; MAGMA statistics). Red dashed line corresponds to the FDR threshold of 0.05. The x axis shows the acronyms for the GWAS data utilized for this analysis. ALZ, Alzheimer's disease; ASD, autism spectrum disorder from IPSYCH (Integrative Psychiatric Research); CognFunc, cognitive functions; EduATT, educational attainment; BMI, body mass index; CAD, coronary artery disease; DIAB, diabetes; HGT, height; OSTEO: osteoporosis.