Fig. 6.

Mock CAR T cells persist less than 3 wk intratumorally, and PCNSL grows unimpededly, while h19m28z CAR T cells eradicate intracerebral U2932tdt cells and persist intracerebrally for more than 14 wk after intracerebral injection. Representative, serial TPLSM images of intracerebral mock CAR T cells (A; green) or h19m28z CAR T cells (B; green) and U2932tdt cells (red). Mosaics of maximum intensity projections with dimensions of 450 × 450 × 400 µm per ROI (until day 28) or 2,387 × 2,387 × 280 µm (day 98) (Movie S5). n = 4 mice per group from 2 independent experiments. (Scale bars: 100 µm.)