Fig. 4.

Reduced antibody production in C3^−/− mice during T. congolense infection. WT and C3^−/− mice (n = 4 per group) were i.p. infected with 1 × 10³ T. congolense. Sera were collected 7 d post infection. Serum titers of IgM (A) and IgG (B) specific for TC13 were measured by ELISA; cutoff points were determined based on O.D. values of samples from naïve mice. Data are expressed as mean ± SEM of 2 independent experiments. **P < 0.01 by Student’s t test.