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. 2019 Nov 22;10:1382. doi: 10.3389/fphar.2019.01382

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Copyright © 2019 Palmer, Souza, dos Santos, Cavalheiro, Schuh, Zucatto, Biazus, Torres, Fregni and Caumo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Timeline of study. On day 0, the socio-demographic questionnaire, Beck Depression Inventory (BDI-II), and Pittsburgh Sleep Quality Index (PSQI) was applied. Day 0: they begin the treatment; day 4: 1st cycle of chemotherapy; Day 11: BDI-II and PSQI and Questionnaire was applied to assess blinding and side effects. (B) Psychophysical measures: Quantitative Sensory Testing (QST) was applied to evaluate the heat pain threshold (HPT), heat pain tolerance (HPTo), and conditioned pain modulation (CPM-test). These measures were assessed on days 0 and 11.