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. Author manuscript; available in PMC: 2020 Jul 16.
Published in final edited form as: Immunity. 2019 Jun 24;51(1):155–168.e5. doi: 10.1016/j.immuni.2019.05.006

Figure 1. Genetic variation between B6-CD45.2 and B6.SJL-CD45.1 mice impacts H3K27Ac in T cells.

Figure 1.

(A, C) H3K27Ac ChIP-seq analyses were performed on (A, C) CD4+ or (A) CD8+ T cells polarized in Th1 conditions. Cells were isolated from (A) conventional (B6-CD45.2) or germ-free (B6.SJL-CD45.1) mice, or (C) B6-CD45.2, B6.SJL-CD45.1, or SJL mice from Jax. (B) Schematic representation of chromosome 1, with the red box indicating a region identified to contain SJL genetic content (Waterstrat et al., 2010). (A, C) UCSC genome browser tracks with genes (below) and cell types or genetic backgrounds (left) indicated. (A, C) Representative of at least 2 independent biological replicates. See also Fig. S1.