| miR-1 |
Regulates TMCs under oxidative stress by targeting FN expression. |
Guo et al. (2019) |
| miR-29b |
Downregulated by TGF-β2 and oxidative stress. Negatively regulates the expression of multiple genes involved in the synthesis and deposition of ECM proteins, including SPARC (secreted protein, acidic, and rich in cysteine), FBN1, laminin, collagens, BMP1, ADAM12, NKIRAS2, and SP1. |
Guadalupe et al. (2011), Li et al. (2009), Luna et al. (2009), Srikumar et al. (2008), Zhaoyong et al. (2009)
|
| miR-21 |
Increases the production of the ECM by silencing its target gene PTEN and by regulating TGF-β2 expression. |
Dang (2017) |
| miR-181a |
Inhibits the TMCs apoptosis induced by H2O2 through the suppression of the NF-κB and JNK pathways. |
Wang et al. (2018) |
| miR-1298 |
Protects TMCs against the damage caused by chronic oxidative stress (COS) via inhibiting the TGF- β2/Smad4 pathway and activating the canonical Wnt pathway. |
Ruibin et al. (2018) |
| miR-483-3p |
Inhibits the ECM after oxidative stress by targeting Smad4. |
Shen et al. (2015) |
| miR-24 |
Regulates TGF β1 during cyclic mechanical stress by targeting FURIN. |
Coralia et al. (2011) |
| miR-200c |
Inhibits the expression of genes (ZEB1, ZEB2, FHOD1, LPAR1/EDG2, ETAR, and RHOA) related to the contraction of TMCs. |
Luna et al. (2012) |
| miR-146a |
Modulates inflammatory markers. |
Guorong et al. (2010) |
| miR-204 |
Affects the sensitivity of TMCs to apoptosis and the number of cells. Acts as a direct target of AP1S2, Bcl2l2, BIRC2, EDEM1, EZR, FZD1, M6PR, RAB22A, RAB40B, SERP1, TCF12, TCF4, CLOCK, PLEKHG5, and ITGB1 MEIS2 and as a potential target of FOXC1. |
Guorong et al. (2011), Matthew et al. (2012), Paylakhi et al. (2013), Redis et al. (2012)
|
| miR-155 |
Regulates the ECM though interacting with the TGF β pathway. |
Bjoern et al. (2006), Johannes et al. (2004)
|
| miR-184 |
Regulates the growth, apoptosis and cytotoxicity by inhibiting HIF-l α. |
Wang et al. (2017) |
| miR-93 |
Inhibits the viability and induces the apoptosis via the suppression of NRF2. |
Wang, Li & Wang (2016) |
| miR-175p |
MiR-17-5p was downregulated in TMCs under oxidative conditions, and may regulate the apoptosis of TMCs by targeting PTEN |
Wang et al. (2019) |
| miR-27a |
Regulates Nrf2 expression at the posttranscriptional level. Salidroside (Sal) mitigates hydrogen peroxide-induced injury by activating the PI3K/AKT and Wnt/b-catenin pathways by increasing miR-27a. |
Zhao et al. (2019a) |
| miR-199-5p |
Targets the 3’-UTR of TGF β2. The increase in TGF β2expression induced by oxidative stress may be related to the downregulation of mir-199-5p expression. |
Feng (2014) |
| miR-182 |
MiR-182 expression is upregulated in primary TMCs with stress-induced premature senescence. The overexpression of miR-182 contributes to the phenotypic alterations of senescent cells. |
Liu et al. (2016) |
| miR-183 |
Decreases the expression of laminin, gel, and type I collagen by targeting ITG β1 without a 3’-UTR. |
Li et al. (2010) |
| miR-450 |
Influences the shrinkage of TMCs by targeting the MyoD family of proteins. |
Sun et al. (2014) |
| miR-107 |
Regulates Nestin expression and counteracts the apoptosis of TMCs. |
Xue et al. (2006) |
| miR-144-3p |
The over-expression of miR-144-3p promotes the proliferation and invasion of TMCs by inhibiting the expression of FN-1 in oxidative stress TMCs |
Yin & Chen (2019) |
| LncRNA-RP11-820 |
Promotes ECM production via regulating miR-3178/MYOD1 |
Shen et al. (2019) |
| LncRNA antisense noncoding RNA in the INK4 locus (ANRIL) |
Down-regulates microRNA-7 to protect TMCs in an experimental model for glaucoma |
Zhao et al. (2019b) |
