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. 2019 Nov 22;10:818. doi: 10.3389/fendo.2019.00818

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Copyright © 2019 Tofte, Suvitaival, Trost, Mattila, Theilade, Winther, Ahluwalia, Frimodt-Møller, Legido-Quigley and Rossing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hazard ratios of prioritized metabolites for progression to the three specific endpoints: all-cause mortality, eGFR decline (>30%) and end-stage renal disease. Hazard ratios (HRs) to the specific endpoints for metabolites that had pBH < 0.05 in crude survival models for the combined renal endpoint. Results for the three endpoints are shown in respective vertically arranged sub-figures. HRs are presented per 1 SD increase of the log2 metabolite and shown for crude model (left) and for model adjusted for age, sex, HbA_1c, systolic blood pressure, smoking, body mass index, statin treatment, p-triglycerides, total p-cholesterol, eGFR, and logUAER (right).