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. 2019 Dec 1;200(11):1434–1439. doi: 10.1164/rccm.201903-0632LE

Table 2.

Adjusted Coefficients for the Associations of Emphysema (%LAA950) and FEV1% Predicted with Cellular Parameters of B-Cell Activation in Separate (Left Columns) and Mutually Adjusted (Right Columns) Linear Regression Models

    Separate Models: %LAA950 or FEV1%pred As Predictor
 Mutually Adjusted Models: Both %LAA950 and FEV1%pred As Predictors
Dependent Variable Predictor Adjusted Coefficient* 95% CI Adjusted P Value Adjusted Coefficient* 95% CI Adjusted P Value
No. of lymphoid follicles/cm2 of lung tissue, log† %LAA950 0.023 0.014, 0.032 <0.001 0.021 0.010, 0.032 <0.001
FEV1%pred −0.009 −0.014, −0.003 0.004 −0.002 −0.008, 0.004 0.505
No. of BAFF+ B cells/cm2 of alveolar tissue, log† %LAA950 0.018 0.010, 0.026 <0.001 0.016 0.006, 0.026 0.003
FEV1%pred −0.007 −0.012, −0.002 0.005 −0.002 −0.007, 0.004 0.517
No. of BAFF+ alveolar cells/cm2 of alveolar tissue, log† %LAA950 0.010 0.005, 0.016 0.001 0.008 0.001, 0.016 0.031
FEV1%pred −0.005 −0.008, −0.001 0.007 −0.002 −0.006, 0.002 0.321
Percentage of CD10+ B cells/total B cells %LAA950 0.326 0.236, 0.415 <0.001 0.338 0.228, 0.449 <0.001
FEV1%pred −0.093 −0.159, −0.027 0.007 0.012 −0.048, 0.072 0.683
Percentage of CD27+ B cells/total B cells %LAA950 0.278 0.093, 0.464 0.004 0.239 0.010, 0.467 0.041
FEV1%pred −0.112 −0.217, −0.007 0.038 −0.037 −0.161, 0.086 0.546
Percentage of CD138+ B cells/total B cells %LAA950 0.377 0.238, 0.516 <0.001 n/a n/a n/a
FEV1%pred −0.049 −0.144, 0.047 0.311 n/a n/a n/a
Percentage of IgG+ B cells/total B cells %LAA950 0.152 0.080, 0.224 <0.001 n/a n/a n/a
FEV1%pred −0.020 −0.065, 0.026 0.395 n/a n/a n/a

Definition of abbreviations: BAFF = B-cell activation factor of the TNF family; CI = confidence interval; FEV1%pred = FEV1% predicted; n/a = not applicable; %LAA950 = low-attenuation areas below a threshold of −950 Hounsfield units.

Models included all patients with chronic obstructive pulmonary disease (without stratification by Global Initiative for Obstructive Lung Disease stage) and smoking control subjects.

*

Also adjusted for sex, age, smoking status, and presence of lung cancer. Pack-years were excluded from the models owing to missing data for three participants. Results were confirmed in a sensitivity analysis after further adjustment for pack-years.

†

Dependent variables were first log-transformed in base 10 to achieve normalization. Participants with no lymphoid follicles were transformed to the base 10 log of 0.1.