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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Clin Colorectal Cancer. 2018 Sep 13;18(1):8–18. doi: 10.1016/j.clcc.2018.08.004

Figure 1.

Figure 1.

Nomogram for overall survival prediction after radioembolization of colorectal cancer liver metastases. Size - sum of largest diameters of two largest liver lesions in intended to-treat-regio; EHD-number of extrahepatic disease sites; CEA-carcinoembryonic antigen level (ng/ml); Alt - alanine aminotransferase (U/L); differentiation- tumor differentiation level.

Example 1 of nomogram points calculation. The patient presented for radioembolization with following parameters: sum of two largest liver lesions diameters of 11.1 cm, two sites of extrahepatic disease, CEA 765.6 ng/ml, albumin of 2.3 g/dl, ALT of 27 U/L and poor tumor differentiation level. By drawing a straight line from the 11.1 cm point on the Size axis of the nomogram to the Points axis we find that a lesion of 11.1 cm corresponded to 25 points. Repeating the same for the other variables, we got 10 points for two sites of extrahepatic disease, 1 point for CEA of 765.6 ng/ml, 45 points for albumin of 2.3 g/dl points, 9 points for ALT of 27 U/L and 27 points for poor tumor differentiation. Sum of these points was 117 and again drawing a straight line from 117 on the Total Points axis to the 1 Year Survival prediction axis we obtained <10 % as the predicted probability of 1-year survival for this patient. The patient had actual overall survival of 1.9 months.

Example 2 of nomogram points calculation. The patient had following baseline characteristics: sum of two largest liver lesions diameters of 1.8 cm, no extrahepatic disease, CEA 2.9 ng/ml, albumin of 4.5 g/dl, ALT of 34 U/L and moderate tumor differentiation level. By drawing a straight line from the 1. 8 cm point on the Size axis of the nomogram to the Points axis we find that a sum of lesions diameters of 1.8 cm corresponded to 4 points. Repeating the same for the other variables, we got 0 points for no extrahepatic disease, 0 points for CEA of 2.9 ng/ml, 9 points for albumin of 4.5 g/dl points, 12 points for ALT of 34 U/L and 0 points for moderate tumor differentiation. Sum of these points was 25 and again drawing a straight line from 25 on the Total Points axis to the 1 Year Survival prediction axis we obtained 90% as the predicted probability of 1-year survival for this patient. The patient had actual overall survival of 60.3 months.