Table 2.
Univariable associations between candidate risk factors and five-year risk of incident atrial fibrillation in the derivation sample.
| Baseline characteristic (N=206,042) | Hazard ratio (95% CI) for incident atrial fibrillation |
|---|---|
| Demographics | |
| Female Sex | 0.54 (0.52–0.57) |
| Age (HR per 10-year increase) | 2.19 (2.14–2.23) |
| Race: White vs. Nonwhite | 1.47 (1.36–1.58) |
| Potential AF risk factors | |
| Smoking | 1.34 (1.25–1.44) |
| Height (per 10-cm increase) | 1.19 (1.16–1.22) |
| Weight (per 15-kg increase) | 1.17 (1.15–1.19) |
| Systolic blood pressure ≥130 mmHg | 1.36 (1.30–1.43) |
| Diastolic blood pressure ≥80 mmHg | 0.83 (0.81–0.85) |
| Hypertension | 1.83 (1.75–1.92) |
| Diabetes | 1.82 (1.71–1.94) |
| Hyperlipidemia | 1.47 (1.40–1.54) |
| Heart failure | 3.85 (3.56–4.15) |
| Coronary heart disease | 2.72 (2.57–2.87) |
| Valvular disease | 3.38 (3.03–3.78) |
| Previous stroke/TIA | 2.29 (2.10–2.50) |
| Vascular disease* | |
| Myocardial infarction | 2.73 (2.53–2.94) |
| Peripheral artery disease | 2.75 (2.55–2.98) |
| Systemic atherosclerosis | 3.08 (2.73–3.48) |
| Cerebral atherosclerosis | 2.62 (2.41–2.85) |
| Chronic kidney disease | 2.56 (2.34–2.80) |
| Thyrotoxicosis | 0.91 (0.75–1.10) |
| Hypothyroidism | 0.95 (0.87–1.03) |
*
Note that presence of at least one of these constituted a criterion for CHA2DS2-VASc