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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Leukemia. 2019 Mar 26;33(10):2429–2441. doi: 10.1038/s41375-019-0454-4

Figure 2. GSK-3β inhibition stabilizes Myc and increases sensitivity to chemotherapy in Myc wild-type Burkitt lymphoma cell lines.

Figure 2.

A) Model of Myc protein regulation by GSK-3β. B) Myc wild type (left) & Thr58 mutant (right) Burkitt lymphoma cell lines were treated with 3 μM CHIR99021 for a 6 hour time course. Western blotting was performed for β-catenin, Myc, MycThr58 phosphorylation and actin control, with Myc quantification using ImageJ below. C) Ramos cells were treated with DMSO or 3 μM CHIR99021 and increasing concentrations of doxorubicin for 72 hours. Cell survival was assessed as in Fig. 1B).