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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Leukemia. 2019 Mar 26;33(10):2429–2441. doi: 10.1038/s41375-019-0454-4

Figure 6. Disrupting the extrinsic apoptotic pathway abrogates the pro-apoptotic effects of anti-GSK-3β adjuvant therapy.

Figure 6.

A) Ramos cells expressing an empty vector construct or the Bcl-2 construct were treated for 2 hours with DMSO or 3 μM CHIR99021 followed by a 6.5 hour time course of .25 μM doxorubicin. Western blotting was performed for Myc, MycThr58 phosphorylation, cleaved PARP, and Bcl-2. B) Ramos cells expressing an empty vector construct or FLIP construct were treated as in A). Western blotting was performed for markers of GSK3-β inhibition, cell death, and FLIP expression.