Figure 7. Anti-GSK-3β adjuvant therapy engages and relies on the extrinsic apoptotic pathway.

A) Ramos derivative cell lines with scrambled gRNA, DR4 gRNA, and DR5 gRNA were treated and cell survival assessed as in Fig. 2C. B) and C) Ramos cells were treated with DMSO or 3 μM CHIR99021 and increasing concentrations of TRAIL (B) or mapatumumab (C) for 72 hours and analyzed as in A).