Table 1. Baseline characteristics and BAT scores of included patients ( n = 156) .
| Age (y) | Median (range) | 42.5 (18–76) |
|---|---|---|
| Sex | Female, n (%) | 120 (76.9) |
| Classification a |
Congenital platelet defect,
n
(%)
Isolated thrombocytopenia ADP pathway defect Glanzmann thrombasthenia TxA2 pathway defect Dense granule deficiency Complex abnormalities b Bernard–Soulier syndrome Possible congenital platelet defect Acquired platelet defect Von Willebrand disease Unexplained bleeding tendency |
77 (48.4) 20 (12.8) 15 (9.6) 13 (8.3) 11 (7.1) 8 (5.1) 6 (3.8) 4 (2.6) 16 (10.3) 3 (1.9) 1 (0.6) 59 (37.8) |
| ISTH-BAT score | Median (range) Score 0 (floor score), n (%) Score > 5 for women, n (%) Score > 3 for men, n (%) |
10 (0–26) 5 (3.2) 104 (86.7) 25 (69.4) |
| Self-BAT score | Median (range) Score 0 (floor score), n (%) Score > 5 for women, n (%) Score > 3 for men, n (%) |
12 (0–33) 2 (1.3) 110 (91.7) 29 (80.6) |
Abbreviations: ADP, adenosine diphosphate; ISTH-BAT, International Society for Thrombosis and Hemostasis–bleeding assessment tool; self-BAT, self-administered ISTH-BAT; TxA2, Thromboxane A2.
a
Final diagnosis at the end of the “Thrombocytopathy in the Netherlands” study.
b
The patterns of platelet function defects did not support the diagnosis of one particular congenital platelet defect.