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. 2019 Nov 29;9:17979. doi: 10.1038/s41598-019-54262-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The results of auditory function tests and vestibular function tests at P 30. (A) ABR testing results. Statistically significant difference is found between the treated and the untreated sides in Slc26a4^−/− mice at 4, 8, 12, 20 and 32 kHz. Each n = 5. ^*P < 0.05 (Mann-Whitney U). (B) Representative track plots for 15 seconds. The Slc26a4^−/− mouse is severely circling, while Slc26a4^+/− and treated Slc26a4^−/− mice are not circling and walking almost normally. (C) This graph shows numbers of rotation per 30 seconds. n = 5. ^*P < 0.05 (Mann-Whitney U). (D) This graph shows walking distance per 30 seconds. n = 5. ^*P < 0.05 (Mann-Whitney U). (E) This graph shows duration of swimming disability. Statistically significant difference is found between the non-treated Slc26a4^−/− mice and the treated Slc26a4^−/− mice as for numbers of rotation, walking distance and duration of swimming disability. n = 5. ^*P < 0.05. ^**P < 0.01 (Mann-Whitney U).