Table 2.
Correlations between chromosomal instability status and clinicopathologic characteristics.
| Clinicopathologic characteristics | Chromosomal instability | p value | |
|---|---|---|---|
| Low | High | ||
| Age | 0.266 | ||
| <50 years | 188 (55.8) | 63 (50.0) | |
| ≥50 years | 149 (44.2) | 63 (50.0) | |
| T stage | 0.007 | ||
| T1 | 157 (46.6) | 41 (32.5) | |
| T2–4 | 180 (53.4) | 85 (67.5) | |
| Lymph node metastasis | 0.010 | ||
| Absent | 195 (57.9) | 56 (44.4) | |
| Present | 142 (42.1) | 70 (55.6) | |
| Histologic grade* | <0.001 | ||
| I & II | 185 (57.3) | 47 (38.2) | |
| III | 138 (42.7) | 76 (61.8) | |
| Lymphovascular invasion | 0.010 | ||
| Absent | 203 (60.2) | 59 (46.8) | |
| Present | 134 (39.8) | 67 (53.2) | |
| Hormone receptor | 0.024 | ||
| Positive | 245 (72.7) | 78 (61.9) | |
| Negative | 92 (27.3) | 48 (38.1) | |
| HER2 status | <0.001 | ||
| Negative | 289 (85.8) | 86 (68.3) | |
| Positive | 48 (14.2) | 40 (31.7) | |
| p53 overexpression* | 0.001 | ||
| Absent | 273 (81.0) | 83 (66.4) | |
| Present | 64 (19.0) | 42 (33.6) | |
| Ki-67 index | <0.001 | ||
| <20% | 217 (64.4) | 53 (42.1) | |
| ≥20% | 120 (35.6) | 73 (57.9) | |
| Molecular subtype | <0.001 | ||
| Luminal/HER2-negative subtype | 224 (66.5) | 59 (46.8) | |
| Luminal/HER2-postive subtype | 21 (6.2) | 19 (15.1) | |
| HER2-positive subtype | 27 (8.0) | 21 (16.7) | |
| Triple-negative subtype | 65 (19.3) | 27 (21.4) | |
| CEP17 copy number gain* | <0.001 | ||
| Absent | 310 (92.8) | 91 (72.2) | |
| Present | 24 (7.2) | 35 (27.8) | |
*There are some missing data.