Table 4.
Univariate and multivariate analyses of disease-free survival in the whole group.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| Onset age (<50 years vs. ≥50 years) | 0.908 (0.538–1.533) | 0.719 | — | — |
| T stage (T1 vs. T2–4) | 2.137 (1.185–3.855) | 0.012 | 1.358 (0.740–2.494) | 0.323 |
| Lymph node metastasis (Absent vs. Present) | 3.402 (1.886–6.135) | <0.001 | 2.528 (1.318–4.850) | 0.005 |
| Histologic grade (I & II vs. III) | 1.309 (0.770–2.226) | 0.320 | — | — |
| Lymphovascular invasion (Absent vs. Present) | 2.904 (1.661–5.077) | <0.001 | 2.037 (1.099–3.775) | 0.024 |
| Hormone receptor (Positive vs. Negative) | 1.687 (0.994–2.863) | 0.053 | 2.002 (1.169–3.430) | 0.011 |
| HER2 status (Negative vs. Positive) | 1.202 (0.636–2.272) | 0.571 | — | — |
| p53 overexpression (Absent vs. Present) | 1.128 (0.616–2.065) | 0.696 | — | — |
| Ki-67 index (<20% vs. ≥20%) | 1.411 (0.840–2.373) | 0.193 | — | — |
| CEP17 copy number gain | 1.546 (0.781–3.062) | 0.211 | — | — |
| CIN (Low vs. High) | 2.270 (1.345–3.831) | 0.002 | 1.813 (1.067–3.080) | 0.028 |