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. 2019 Nov 29;9:17996. doi: 10.1038/s41598-019-54401-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential methylation between primary versus recurrent high-grade serous ovarian cancer, and optimal versus suboptimal surgical outcomes. (A) Heat map of methylation probes that interrogating known genes in primary and recurrent high-grade serous ovarian cancer (HGSOC). (B) Pathways significantly enriched with genes that are differentially methylated between primary and recurrent HGSOC in the KEGG database. (C) Heat map of methylation probes that interrogating known genes for optimal versus suboptimal surgical outcomes in primary HGSOC. Optimal outcomes defines as residual disease of <1 cm, survival of >90 days after surgery, and chemotherapy administration within 8 weeks after surgery. (D) Experimental flow showing gene expression for probes representing specific loci differentially methylated between optimal and suboptimal surgical outcomes in primary HGSOC. Initial analysis focused on inverse correlations between methylation status (hypermethylated or hypomethylated) and degree of gene expression (increased or decreased). (E) List of genes presenting inverse correlations between methylation status and degree of gene expression.