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. 2019 Nov 29;9:17996. doi: 10.1038/s41598-019-54401-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global methylation status and promoter methylation status in high-grade serous ovarian cancer. (A) Global methylation status was evaluated using probes that identify isolated loci of methylated CpGs in the open sea regions of the genome defined as >4 Kb away from the nearest CpG island. Each dot represents a cluster of long methylated DNA segments (B). Promoter methylation status was evaluated using probes that identify shorter genomic regions of CpGs. Each dot represents a cluster of contiguous CpG regions knows as CpG islands and/or shorelines. The alternating shades of color are used to differentiate a cluster located in one chromosome from another in a different chromosome. In (A,B) the numbers on the X- axis represent chromosomes. The dots appearing above the red line represent hypermethylated regions, while those appearing below are hypomethylated.