Table 2.
Genera differing significantly within the tested attribute family.
| Peptoniphilus | Finegoldia | Anaerococcus | Eubacterium brachy group | Faecalibacterium | Fusicatenibacter | Ruminococcus gauvreauii group | Sellimonas | Bifidobacterium | Streptococcus | Enterococcus | Dielma | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease | |||||||||||||
| Ctrl/PD |
P(FDR) A/B |
<0.001 0.00 |
0.019 3.06 |
0.035 12.56 |
|||||||||
| Sex | |||||||||||||
| Ctrl-f/Crtl-m |
P(FDR) A/B |
0.005 12.60 |
|||||||||||
| PD-f/PD-m |
P(FDR) A/B |
||||||||||||
| Ctrl-f/PD-f |
P(FDR) A/B |
<0.001 0.00 |
0.009 9.89 |
||||||||||
| Ctrl-m/PD-m |
P(FDR) A/B |
||||||||||||
| Calprotectin | |||||||||||||
| Ctrl−/PD− |
P(FDR) A/B |
0.0192 0.00 |
|||||||||||
| Ctrl−/PD+ |
P(FDR) A/B |
<0.001 0.00 |
<0.001 0.33 |
<0.001 31.20 |
0.004 62.00 |
||||||||
| Ctrl−/Ctrl+ |
P(FDR) A/B |
0.048 8.50 |
0.048 0.61 |
||||||||||
| L-dopa | |||||||||||||
| Ctrl−/PD− |
P(FDR) A/B |
||||||||||||
| Ctrl−/PD+ |
P(FDR) A/B |
<0.001 0.00 |
0.019 0.00 |
<0.001 04.69 |
0.038 2.06 |
||||||||
| Ctrl−/Ctrl+ |
P(FDR) A/B |
||||||||||||
| Entacapone | |||||||||||||
| Ctrl−/PD− |
P(FDR) A/B |
0.019 0.00 |
|||||||||||
| Ctrl−/PD+ |
P(FDR) A/B |
<0.001 0.00 |
0.025 0.20 |
0.025 0.75 |
0.025 10.25 |
0.03 51.00 |
0.031 0.09 |
0.009 0.29 |
0.025 0.90 |
||||
| Ctrl−/Ctrl+ |
P(FDR) A/B |
0.01 0.26 |
<0.001 0.03 |
||||||||||
| Phenotype | |||||||||||||
| Ctrl/E |
P(FDR) A/B |
||||||||||||
| Ctrl/HR |
P(FDR) A/B |
<0.001 0.00 |
<0.001 16.65 |
||||||||||
| Ctrl/T |
P(FDR) A/B |
||||||||||||
| Ctrl/E |
P(FDR) A/B |
||||||||||||
| E/HR |
P(FDR) A/B |
||||||||||||
| E/T |
P(FDR) A/B |
||||||||||||
| HR/T |
P(FDR) A/B |
||||||||||||
| Hoehn Yahr stage | |||||||||||||
| Ctrl/HY 1-2.5 |
P(FDR) A/B |
<0.001 0.00 |
0.029 7.61 |
||||||||||
| Ctrl/HY 3-4 |
P(FDR) A/B |
<0.001 0.00 |
|||||||||||
| HY 1-2.5/HY3-4 |
P(FDR) A/B |
||||||||||||
Shown are the p-values for genera that differed significantly between the tested attributes. The quotient of relative abundances for each genus (A/B) indicates whether the genus relatively increased (>1) or decreased (<1) in the second attribute when compared to the first attribute. All p-values are based on false discovery correction for multiple testing (FDR) calculated within the attribute family. Compared were the control (Ctrl) and the Parkinson (PD) samples, and the attributes female (f) and male (m) in the sex attribute family, positive (+) and negative (−) detection of calprotectin in the fecal samples and medication (+) or no medication (−) with entacapone or L-dopa. Also shown are the PD phenotypes hypokinetic-rigid (HR), tremordominant (T) and equivalent (E) and the Hoehn Yahr stages HY 1-4