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. 2019 Nov 29;10:5462. doi: 10.1038/s41467-019-13382-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Genes associated with kidney diseases are expressed in expected compartments across organoids from four human iPSC lines. Heatmap of cell-type-specific gene expression (ThF line, ML protocol) in organoids and human adult kidney. Genes implicated in monogenic causes of a congenital abnormalities of the kidney and urinary tract (CAKUT), and b mendelian renal cystic diseases and tumor syndromes. c IF staining validates the expression of MUC1 and PAX2 in the distal tubule in D29 kidney organoids. CDH1 serves a distal tubular marker. Note appropriate apical expression of MUC1 in distal tubular epithelial cells.