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. 2019 Nov 29;9:17992. doi: 10.1038/s41598-019-54312-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Physical interaction of TBX5 with HDACs and functional consequences. (A) Pull-down assay showing the physical interaction between TBX5 and class I and class II HDACs. HDACs (1–5) interact with TBX5, whereas HDAC6 does not (IP: immunoprecipitation and IB: Immunoblot). Full-length blots are shown in Supplementary Fig. S1. (B,C) Luciferase-reporter assays showing that class I histone deacetylase HDAC1 and class II histone deacetylases HDAC4 and 5 repress TBX5-mediated transcriptional activity on the MYH6 promoter. Results are from three individual experiments. Error bars represent SD, *P < 0.02, **P < 0.01. Inset showing the Fold changes.