Table 2.
Association of plasma lipid profiles and odds of carotid plaque.
| Odds ratios (95% CI) for carotid plaque | Odds ratios (95% CI) for common carotid artery plaque | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P-trend | Q1 | Q2 | Q3 | Q4 | p-trend | |
| TG | ||||||||||
| Cases/N | 684 | 678 | 677 | 680 | 680 | 670 | 686 | 662 | ||
| Model 1 | 1.00 | 1.05(0.81–1.35) | 1.05(0.81–1.35) | 1.19(0.92–1.53) | 0.199 | 1.00 | 1.07(0.83–1.38) | 1.07(0.82–1.38) | 1.22 (0.95–1.58) | 0.135 |
| Model 2 | 1.00 | 0.87(0.65–1.14) | 0.82(0.61–1.10) | 0.85(0.63–1.15) | 0.309 | 1.00 | 0.90(0.68–1.20) | 0.84(0.63–1.13) | 0.90 (0.66–1.22) | 0.471 |
| TC | ||||||||||
| Cases/N | 680 | 670 | 686 | 662 | 680 | 670 | 686 | 662 | ||
| Model 1 | 1.00 | 0.96(0.75–1.24) | 1.16(0.91–1.49) | 1.25 (0.98–1.60) | 0.029 | 1.00 | 0.98(0.76–1.27) | 1.28(0.99–1.64) | 1.35(1.05–1.74)* | 0.004 |
| Model 2 | 1.00 | 0.94(0.72–1.23) | 1.10(0.85–1.43) | 1.16(0.89–1.52) | 0.140 | 1.00 | 0.96(0.73–1.25) | 1.22(0.93–1.59) | 1.25(0.96–1.64) | 0.030 |
| HDLc | ||||||||||
| Cases/N | 685 | 658 | 707 | 659 | 685 | 658 | 707 | 659 | ||
| Model 1 | 1.00 | 1.01(0.79–1.29) | 0.83(0.65–1.06) | 0.74(0.58–0.95)* | 0.008 | 1.00 | 0.96(0.75–1.23) | 0.89(0.70–1.14) | 0.77(0.60–0.99)* | 0.040 |
| Model 2 | 1.00 | 0.93(0.72–1.21) | 0.74(0.57–0.97)* | 0.63(0.47–0.85)** | 0.001 | 1.00 | 0.92(0.71–1.20) | 0.81(0.62–1.07) | 0.69(0.52–0.93)* | 0.009 |
| LDLc | ||||||||||
| Cases/N | 679 | 656 | 671 | 649 | 679 | 656 | 671 | 649 | ||
| Model 1 | 1.00 | 0.81(0.63–1.05) | 1.22(0.95–1.56) | 1.35(1.05–1.73)* | 0.001 | 1.00 | 0.82(0.63–1.06) | 1.23(0.96–1.58) | 1.44(1.12–1.85)** | <0.001 |
| Model 2 | 1.00 | 0.77(0.59–1.01) | 1.12(0.87–1.46) | 1.30(0.99–1.69) | 0.005 | 1.00 | 0.79(0.60–1.03) | 1.15 (0.89–1.50) | 1.41(1.09–1.84)* | 0.001 |
| Non-HDLc | ||||||||||
| Cases/N | 670 | 681 | 678 | 659 | 670 | 681 | 678 | 659 | ||
| Model 1 | 1.00 | 1.06(0.82–1.37) | 1.27(0.99–1.64) | 1.45(1.12–1.86)** | 0.001 | 1.00 | 1.13(0.87–1.46) | 1.44(1.11–1.85)** | 1.59(1.23–2.05)*** | <0.001 |
| Model 2 | 1.00 | 1.06(0.81–1.39) | 1.18(0.90–1.54) | 1.36(1.04–1.78)* | 0.018 | 1.00 | 1.13(0.86–1.49) | 1.33(1.02–1.75)* | 1.49(1.13–1.97)** | 0.002 |
| TC/HDLc | ||||||||||
| Cases/N | 677 | 668 | 676 | 667 | 677 | 668 | 676 | 667 | ||
| Model 1 | 1.00 | 1.08(0.84–1.39) | 1.25(0.97–1.62) | 1.50(1.16–1.93)** | 0.001 | 1.00 | 1.05(0.81–1.35) | 1.31(1.01–1.69)* | 1.53(1.19–1.98)** | <0.001 |
| Model 2 | 1.00 | 1.10(0.84–1.44) | 1.19(0.91–1.57) | 1.47(1.12–1.94)** | 0.004 | 1.00 | 1.06(0.80–1.39) | 1.24(0.94–1.63) | 1.49(1.13–1.97)** | 0.002 |
| LDLc/HDLc | ||||||||||
| Cases/N | 675 | 676 | 673 | 685 | 676 | 664 | 659 | 652 | ||
| Model 1 | 1.00 | 1.28(0.99–1.65) | 1.16(0.90–1.50) | 1.76(1.36–2.27)*** | <0.001 | 1.00 | 1.22(0.95–1.58) | 1.21(0.93–1.56) | 1.76(1.36–2.27)*** | <0.001 |
| Model 2 | 1.00 | 1.22(0.93–1.59) | 1.10(0.84–1.45) | 1.74(1.32–2.29)*** | <0.001 | 1.00 | 1.17(0.89–1.53) | 1.14(0.87–1.50) | 1.72(1.31–2.26)*** | <0.001 |
| TG/HDLc | ||||||||||
| Cases/N | 684 | 678 | 677 | 680 | 675 | 676 | 673 | 685 | ||
| Model 1 | 1.00 | 1.06(0.82–1.37) | 1.14(0.89–1.47) | 1.24(0.96–1.60) | 0.077 | 1.00 | 1.02(0.79–1.32) | 1.11(0.86–1.44) | 1.22(0.95–1.58) | 0.092 |
| Model 2 | 1.00 | 0.98(0.75–1.29) | 1.05 (0.79–1.38) | 1.08(0.81–1.43) | 0.524 | 1.00 | 0.94(0.71–1.24) | 1.01(0.76–1.34) | 1.04(0.79–1.39) | 0.625 |
TC: total cholesterol; TG: triglycerides; HDLc: high-density lipoprotein cholesterol; LDLc: low-density lipoprotein cholesterol; CCA: common carotid artery, ICA: internal carotid artery; ECA: external carotid artery; Q1: Quantiles 1; Q2: Quantiles 2; Q3: Quantiles 3; Q4: Quantiles 4.
Model 1: adjusted for age (years, continuous variable), sex (male or female), and BMI (continuous variable); Model 2: further adjusted for systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose, uric acid, TC (not for TC vs. atherosclerosis), TG (not for TG vs. atherosclerosis), HDLc(not for HDLc vs. atherosclerosis) and LDLc (not for LDLc vs. atherosclerosis)
Compared with the lowest quarter: *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001.