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. 2019 Nov 29;10:5460. doi: 10.1038/s41467-019-13394-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Transcription inhibition reduces AAG occupancy and impairs removal of AAG substrates. a–d ChIP-qPCR experiments comparing AAG occupancy in DMSO and DRB treated HEK293T WT cells at ALDH1A2 (a), CRMP1 (b), CDH23 (c), and YTHDC1 (d) genes. Error bars, SEM from three independent experiments. e AAG Comet-FLARE assay in DMSO or DRB treated HEK293T cells. Error bars indicate mean ± SEM (n ≥ 3). **p ≤ 0.01; ***p ≤ 0.001, one-way ANOVA. Source data are provided as Source Data file.