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. 2019 Nov 29;9:17936. doi: 10.1038/s41598-019-54283-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trial 2 Immunohistochemistry (Day 5 Treatment). IHC staining of brain samples from Untreated Control (CTR) (top row), UC-1- (middle row), and UC-2-treated rats (bottom row) that died spontaneously from 9L gliosarcoma at days 12, 43, and 30, respectively. For each pair of images, left is 2.5× magnification of the area at the margin between tumor and healthy tissue and right is 20× magnification of healthy tissue in proximity to tumor margin (general location demonstrated by square boxes in 2.5× photos). Anti-NeuN (a) and anti-GFAP (b) staining demonstrates no qualitative decrease in signal from healthy neurons and astrocytes among treated brains compared to control. Images of astrocytes and neurons were obtained from hippocampal and cortical areas, adjacent to the tumor margin near wafer implant.