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. 2019 Nov 29;9:17931. doi: 10.1038/s41598-019-54213-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional profiles of BL/LL and TT/BT patients without reactions. Gene expression levels of 103 target genes were assessed by dual-color RT-MLPA performed on ex vivo RNA isolated from whole blood of newly diagnosed, untreated BL/LL (n = 228; black circles) and TT/BT (n = 131; grey circles) leprosy patients without reactions from Bangladesh, Brazil, Ethiopia and Nepal. Log2-transformations of peak areas (normalized to the housekeeping gene GAPDH) of genes that were significantly differentially expressed between BL/LL and TT/BT are shown on the y-axis. Raw p-values were calculated using the Mann–Whitney test and adjusted for multiple comparisons using the Benjamini-Hochberg correction⁴⁰. *adjusted p-values < 0.05; **adjusted p-values < 0.01; (see Table S5).