Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 29;9:17931. doi: 10.1038/s41598-019-54213-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Identification of a minimal biomarker risk signature for developing reversal reactions. Biomarker signature to assess the risk of BL/LL patients to develop reversal reactions (RR). Gene expression data obtained by dual-color RT-MLPA of RNA isolated from whole blood of BL/LL patients from Bangladesh, Brazil, Ethiopia and Nepal at t = 0 were analyzed using the global test cluster analysis⁴¹. The global test is a cluster analysis based on absolute correlation difference and average linkage developed for data sets in which many covariates (or features) have been measured for the same subjects, together with a response variable. Graphs (A,B) indicate genes that are higher expressed in future RR patients (red) or in non-reactional BL/LL patients (green). In (A) all genes analyzed are shown and in (B) only significant branches are shown. Table (C) shows values for the 5 genes that were statistically significant after correction for multiple testing (inheritance <0.05), representing the output signature of the global test shrinkage model.