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. 2019 Nov 29;9:17931. doi: 10.1038/s41598-019-54213-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intra-individual longitudinal expression of patients who developed RR. Direct ex vivo RNA expression values were assessed by dual-color RT-MLPA on whole blood of 10 leprosy patients who developed RR during this study. Blood was analyzed at three time points: in the absence of any clinical signs of reactions and at least two months before RR (t = 0), at RR diagnosis before steroids (t = x) or after MDT and at least one month after end of steroids, in the absence of reactions (t = end). Log2-transformations of peak areas (normalized for GAPDH expression) are shown on the y-axis. Wilcoxon signed-rank test was performed. Genes with a significant difference (p-value < 0.05) in expression between before RR-at RR and at RR-after RR are shown.