Table 2.
Level of evidence relevant to the psychometric properties of rheumatoid arthritis disease activity measures.
| RADAM | Internal Consistency | Reliability | Measurement Error | Content Validity | Structural Validity | Hypotheses testing | Responsiveness |
|---|---|---|---|---|---|---|---|
| Clinical Disease Activity Index (CDAI) | + | ++ | + | ++ | +++ | +++ | |
| Modified CDAI (Baker) | ++ | ||||||
| Patient derived CDAI | + | + | + | ||||
| Disease Activity Score (DAS) | ++ | ||||||
| Disease Activity Score 28 joints (DAS28) | ++ | ++ | ++ | −−− | ++ | +++ | +++ |
| Modified DAS28 (Baker) | ++ | ||||||
| Modified DAS28 (Bentley) | ? | ++ | ++ | ||||
| Patient derived DAS28 | ++ | + | ++ | + | |||
| Ultrasound derived DAS28 | + | ++ | + | ||||
| Global Arthritis Score (GAS) | ++ | ++ | |||||
| Hospital Universitario La Princesa Index (HUPI) | ? | ++ | ++ | ||||
| Individualized Ultrasound Score | ? | ||||||
| Individualized Composite Ultrasound Score | ? | ||||||
| Kappa/Lambda hybrid antibody | + | ||||||
| Mean Overall Index for RA (MOI-RA) | + | + | |||||
| Multi-biomarker Disease Activity Score (MBDA) | ? | +++ | +++ | ++ | ++ | ||
| Optical Spectral Transmission (OST) | ++ | ||||||
| Patient Activity Scale (PAS) | + | + | |||||
| Patient Activity Scale-II (PAS-II) | |||||||
| Patient Based Disease Activity Score (PDAS1) | + | + | |||||
| Patient Based Disease Activity Score (PDAS2) | + | + | |||||
| Patient Reported Clinical Arthritis Activity (PRO-CLARA) | + | ? | ++ | + | |||
| Rheumatoid Arthritis Disease Activity Index (RADAI) | ? | ? | ++ | ++ | |||
| Rheumatoid Arthritis Disease Activity Index 5 (RADAI-5) | ? | ++ | ++ | ||||
| Rheumatoid Arthritis MRI scoring (RAMRIS) | −− | − | |||||
| Routine Assessment of Patient Index Data 3 (RAPID-3) | ? | ? | ? | +++ | +++ | +++ | |
| Routine Assessment of Patient Index Data 4 (RAPID-4) | ++ | + | |||||
| Routine Assessment of Patient Index Data 5 (RAPID-5) | ++ | ++ | |||||
| Simplified Disease Activity Index (SDAI) | + | ++ | + | +++ | +++ | ||
| Modified SDAI (Baker) | ++ | ||||||
| Patient derived SDAI | + | + | ++ | ||||
| Ultrasound derived SDAI | + | ++ | + | ||||
| Simplified RA MRI Score (SAMIS) | + | ? | |||||
| Swiss Sonography in Arthritis and Rheumatism (SONAR) Score | ? | ? | ++ | ++ | |||
| Ultrasound 6 joint (Perricone) | +++ | + | + | ||||
| Ultrasound 6 joint (Rosa) | + | ||||||
| Ultrasound 6 joint (Kawashiri) | ? | ||||||
| Ultrasound 7 joint (Backhaus) | ++ | +++ | ++ | ++ | |||
| Ultrasound 8 joint (Yoshimi) | +++ | ++ | |||||
| Ultrasound 12 joint (Naredo) | + | +++ | + | + | |||
| Ultrasound 14 joint (Dale) | ? | ||||||
| Ultrasound 20 joint (Dougados) | ? | + | ++ | ||||
| Ultrasound 28 joint (Dougados) | ? | + | ++ | ||||
| Ultrasound 38 joint (Dougados) | ? | + | ++ | ||||
| Ultrasound 78 joint (Hammer) | ? | ? | ? | ||||
| Ultrasound Score A and B (Aga) | +++ | + | + |
Level of evidence grading:
Strong, +++ or −−−, Consistent findings in multiple studies of good methodological quality –OR- in one study of excellent methodological quality
Moderate, ++ or −−, Consistent findings in multiple studies of fair methodological quality –OR- in one study of good methodological quality
Limited, + or −, One study of fair methodological quality
Conflicting, ±, Conflicting findings
Unknown, ?, Studies only of poor methodological quality