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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Pharmacol Res. 2019 Nov 2;150:104502. doi: 10.1016/j.phrs.2019.104502

Fig 2. Schematic of toll-like receptor 4 (TLR4) interactions with accessory proteins.

Fig 2.

(A) Extracellular LPS binds LPS-binding protein (LBP). From there, LPS is transferred to CD14, which is associated with the ectodomain of TLR4. (B) CD14 facilitates recognition of LPS by transferring it to the complex of TLR4 and myeloid differentiation factor 2 (MD-2).