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. 2019 Jul 26;11(10):886–898. doi: 10.1093/jmcb/mjz080

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© The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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ncRNAs are directly involved in chromosome translocation. (A) ncRNA-convergent fusions. (B) The chromosomal translocation sites reside in the ncRNA regions: production of new ncRNAs by juxtaposition of regulatory elements upstream of non-coding regions or disruption of original ncRNA. (C) The fusions of non-coding regions with coding regions lead to the dysregulations of coding products and subsequent alterations of related signaling pathways. (D) The coding fusion transcripts or the derived non-coding isoforms, such as circRNAs by back-splicing, function as regulatory RNAs.