Table 1.

Gene copy number, cellular viability and TOP1 enzymatic activity in selected cell lines

Cell line	BC subtype	TOP1 Gene copy number	Viability IC50 (μM)	TOP1 Enzymatic activity
MCF7	Luminal	3	0.089 ± 0.017	High
HCC1428	Luminal	No amplification	0.448 ± 0.054	Low
HCC202	HER 2	No amplification	0.481 ± 0.060	Low
HCC1419	HER 2	5.5	0.067 ± 0.010	High
MDAB231	TNBC	2.8	0.040 ± 0.011	Low
MDAMB453	TNBC	2.6	0.058 ± 0.019	Low
BT549	TNBC	2.6	0.056 ± 0.007	Low
SUM149	TNBC	2.4	0.065 ± 0.010	Low