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. 2019 Nov 29;12:569. doi: 10.1186/s13071-019-3823-y

Table 3.

List of the differentially expressed genes mapped to representative immune-related pathways by KEGG pathway analysis

Sl no Gene code Description Fold change Regulation
Chemokine signaling
 1 ADCY9 Adenylate cyclase type 9 3.59 Up
 2 CCL11 C-C motif chemokine 11/eotaxin 9.56 Up
 3 CCL4 C-C motif chemokine 4 13.42 Up
 4 CCR5 C-C chemokine receptor type 5-like 4.31 Up
 5 CXCL12 Stromal cell-derived factor 1 precursor 3.0 Up
 6 CXCL13 C-X-C motif chemokine 13-like 4.99 Up
 7 CXCR1 C-X-C chemokine receptor type 1-like 4.47 Up
 8 CXCR3 C-X-C chemokine receptor type 3-like − 2.49 Down
 9 CXCR5 C-X-C chemokine receptor type 5-like 2.64 Up
 10 FOXO3 Forkhead box O3 4.36 Up
 11 GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 3.53 Up
 12 PXN Paxillin-like 3.11 Up
NOD-like receptor signaling
 1 ATG16L1 Autophagy related 16-like 1 2.88 Up
 2 ATG5 Autophagy related 5 homolog 4.89 Up
 3 CASR Extracellular calcium-sensing receptor-like protein 3.26 Up
 4 CTSB Cathepsin B − 3.01 Down
 5 IFNAR1 Interferon alpha/beta receptor 1a-like 2.34 Up
 6 IFNAR2 Interferon alpha/beta receptor 2 2.72 Up
 7 JUN Transcription factor AP-1-like 3.75 Up
 8 NLRP3 NACHT, LRR and PYD domains-containing protein 3 − 2.37 Down
 9 PYCARD Apoptosis-associated speck-like protein containing a CARD 2.53 Up
 10 RIPK3 Receptor-interacting serine/threonine-protein kinase 3 2.70 Up
Natural killer cell mediated cytotoxicity
 1 BID BH3-interacting domain death agonist-like 2.77 Up
 2 ICAM1 Intercellular adhesion molecule 1-like isoform X2 − 7.45 Down
 3 IFNAR1 Interferon alpha/beta receptor 1a-like 2.34 Up
 4 IFNAR2 Interferon alpha/beta receptor 2 2.72 Up
 5 IFNGR1 Interferon gamma receptor 1a 2.33 Up
 6 IGH Immunoglobulin heavy chain 147.29 Up
 7 ITGB2 Integrin beta-2-like 3.0 Up
 8 PRF1 Perforin-1-like − 3.18 Down
 9 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 2.81 Up
Th17 cell differentiation
 1 CD3E CD3epsilon 5.68 Up
 2 IFNGR1 Interferon gamma receptor 1a 2.33 Up
 3 IL21R Interleukin-21 receptor-like 2.69 Up
 4 IL6ST Interleukin-6 receptor subunit beta-like 3.28 Up
 5 IRF4 Interferon regulatory factor 4 7.28 Up
 6 JUN Transcription factor AP-1-like 3.75 Up
 7 NFKBIE Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 9.05 Up
 8 TGFBR1 TGF-beta receptor type-1 − 2.14 Down
Hematopoietic cell lineage
 1 CD2 T-cell surface antigen CD2 2.89 Up
 2 CD22 B-cell receptor CD22-like 3.10 Up
 3 CD34 Hematopoietic progenitor cell antigen CD34-like − 3.13 Down
 4 CD3E CD3epsilon 5.68 Up
 5 CR2 Complement receptor type 2-like 3.25 Up
 6 IGH Immunoglobulin heavy chain 147.29 Up
 7 MME Neprilysin-like − 4.06 Down
 8 TFRC Transferrin receptor protein 1-like 4.97 Up
B cell receptor signaling
 1 BLNK B-cell linker protein-like isoform X1 3.43 Up
 2 CD22 B-cell receptor CD22-like 3.10 Up
 3 CD79A B-cell antigen receptor complex-associated protein alpha chain-like 2.76 Up
 4 CR2 Complement receptor type 2-like 3.25 Up
 5 IGH Immunoglobulin heavy chain 147.29 Up
 6 JUN Transcription factor AP-1-like 3.75 Up
 7 NFKBIE Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 9.05 Up
Th1 and Th2 cell differentiation
 1 CD3E CD3 epsilon 5.68 Up
 2 IFNGR1 Interferon gamma receptor 1a 2.33 Up
 3 IL12B Interleukin-12 subunit beta-like 2.31 Up
 4 IL12RB2 Interleukin-12 receptor subunit beta-2-like 3.50 Up
 5 JUN Transcription factor AP-1-like 3.75 Up
 6 NFKBIE Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 9.05 Up
Complement and coagulation cascades
 1 A2M Alpha-2-macroglobulin-like − 7.82 Down
 2 C8G Complement C8 gamma chain − 5.78 Down
 3 CR2 Complement receptor type 2-like 3.25 Up
 4 F2RL2 Proteinase-activated receptor 3-like (coagulation factor II (thrombin) receptor) 5.81 Up
 5 ITGB2 Integrin beta-2-like 3.0 Up
 6 PLAUR Urokinase plasminogen activator surface receptor-like − 3.17 Down

Notes: Chemokine signaling pathway has the predominant share of differentially expressed genes among the immune related pathways. Interestingly, most of the immune genes were upregulated in the T. bryosalmonae-exposed posterior kidney of brown trout