Table 3.
Sl no | Gene code | Description | Fold change | Regulation |
---|---|---|---|---|
Chemokine signaling | ||||
1 | ADCY9 | Adenylate cyclase type 9 | 3.59 | Up |
2 | CCL11 | C-C motif chemokine 11/eotaxin | 9.56 | Up |
3 | CCL4 | C-C motif chemokine 4 | 13.42 | Up |
4 | CCR5 | C-C chemokine receptor type 5-like | 4.31 | Up |
5 | CXCL12 | Stromal cell-derived factor 1 precursor | 3.0 | Up |
6 | CXCL13 | C-X-C motif chemokine 13-like | 4.99 | Up |
7 | CXCR1 | C-X-C chemokine receptor type 1-like | 4.47 | Up |
8 | CXCR3 | C-X-C chemokine receptor type 3-like | − 2.49 | Down |
9 | CXCR5 | C-X-C chemokine receptor type 5-like | 2.64 | Up |
10 | FOXO3 | Forkhead box O3 | 4.36 | Up |
11 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | 3.53 | Up |
12 | PXN | Paxillin-like | 3.11 | Up |
NOD-like receptor signaling | ||||
1 | ATG16L1 | Autophagy related 16-like 1 | 2.88 | Up |
2 | ATG5 | Autophagy related 5 homolog | 4.89 | Up |
3 | CASR | Extracellular calcium-sensing receptor-like protein | 3.26 | Up |
4 | CTSB | Cathepsin B | − 3.01 | Down |
5 | IFNAR1 | Interferon alpha/beta receptor 1a-like | 2.34 | Up |
6 | IFNAR2 | Interferon alpha/beta receptor 2 | 2.72 | Up |
7 | JUN | Transcription factor AP-1-like | 3.75 | Up |
8 | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | − 2.37 | Down |
9 | PYCARD | Apoptosis-associated speck-like protein containing a CARD | 2.53 | Up |
10 | RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | 2.70 | Up |
Natural killer cell mediated cytotoxicity | ||||
1 | BID | BH3-interacting domain death agonist-like | 2.77 | Up |
2 | ICAM1 | Intercellular adhesion molecule 1-like isoform X2 | − 7.45 | Down |
3 | IFNAR1 | Interferon alpha/beta receptor 1a-like | 2.34 | Up |
4 | IFNAR2 | Interferon alpha/beta receptor 2 | 2.72 | Up |
5 | IFNGR1 | Interferon gamma receptor 1a | 2.33 | Up |
6 | IGH | Immunoglobulin heavy chain | 147.29 | Up |
7 | ITGB2 | Integrin beta-2-like | 3.0 | Up |
8 | PRF1 | Perforin-1-like | − 3.18 | Down |
9 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | 2.81 | Up |
Th17 cell differentiation | ||||
1 | CD3E | CD3epsilon | 5.68 | Up |
2 | IFNGR1 | Interferon gamma receptor 1a | 2.33 | Up |
3 | IL21R | Interleukin-21 receptor-like | 2.69 | Up |
4 | IL6ST | Interleukin-6 receptor subunit beta-like | 3.28 | Up |
5 | IRF4 | Interferon regulatory factor 4 | 7.28 | Up |
6 | JUN | Transcription factor AP-1-like | 3.75 | Up |
7 | NFKBIE | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 9.05 | Up |
8 | TGFBR1 | TGF-beta receptor type-1 | − 2.14 | Down |
Hematopoietic cell lineage | ||||
1 | CD2 | T-cell surface antigen CD2 | 2.89 | Up |
2 | CD22 | B-cell receptor CD22-like | 3.10 | Up |
3 | CD34 | Hematopoietic progenitor cell antigen CD34-like | − 3.13 | Down |
4 | CD3E | CD3epsilon | 5.68 | Up |
5 | CR2 | Complement receptor type 2-like | 3.25 | Up |
6 | IGH | Immunoglobulin heavy chain | 147.29 | Up |
7 | MME | Neprilysin-like | − 4.06 | Down |
8 | TFRC | Transferrin receptor protein 1-like | 4.97 | Up |
B cell receptor signaling | ||||
1 | BLNK | B-cell linker protein-like isoform X1 | 3.43 | Up |
2 | CD22 | B-cell receptor CD22-like | 3.10 | Up |
3 | CD79A | B-cell antigen receptor complex-associated protein alpha chain-like | 2.76 | Up |
4 | CR2 | Complement receptor type 2-like | 3.25 | Up |
5 | IGH | Immunoglobulin heavy chain | 147.29 | Up |
6 | JUN | Transcription factor AP-1-like | 3.75 | Up |
7 | NFKBIE | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 9.05 | Up |
Th1 and Th2 cell differentiation | ||||
1 | CD3E | CD3 epsilon | 5.68 | Up |
2 | IFNGR1 | Interferon gamma receptor 1a | 2.33 | Up |
3 | IL12B | Interleukin-12 subunit beta-like | 2.31 | Up |
4 | IL12RB2 | Interleukin-12 receptor subunit beta-2-like | 3.50 | Up |
5 | JUN | Transcription factor AP-1-like | 3.75 | Up |
6 | NFKBIE | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 9.05 | Up |
Complement and coagulation cascades | ||||
1 | A2M | Alpha-2-macroglobulin-like | − 7.82 | Down |
2 | C8G | Complement C8 gamma chain | − 5.78 | Down |
3 | CR2 | Complement receptor type 2-like | 3.25 | Up |
4 | F2RL2 | Proteinase-activated receptor 3-like (coagulation factor II (thrombin) receptor) | 5.81 | Up |
5 | ITGB2 | Integrin beta-2-like | 3.0 | Up |
6 | PLAUR | Urokinase plasminogen activator surface receptor-like | − 3.17 | Down |
Notes: Chemokine signaling pathway has the predominant share of differentially expressed genes among the immune related pathways. Interestingly, most of the immune genes were upregulated in the T. bryosalmonae-exposed posterior kidney of brown trout