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. 2019 Nov 29;10:360. doi: 10.1186/s13287-019-1442-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Therapeutic effect of BMSC-derived exosomes on POF. a Protocol for mouse model of POF. b HE staining of ovarian tissue was performed to observe the morphological differences of follicles (under (× 100) magnification, arrows point to atretic follicles). c The difference in the expression of cleaved-caspase3 in the ovarian tissue was analyzed by immunohistochemistry (scale bar, 5.0 μm) ^*P<0.05 vs.control group, ^#P<0.05 vs. POF group. d The difference expression of P53 in the ovarian tissue was detected by Western blot. e The concentration of E2 in the serum was detected by ELISA ^**P<0.01 vs.control group, ^##P<0.01vs. POF group. Data are expressed as mean ± standard deviation (SD)