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. 2019 Nov 29;21:131. doi: 10.1186/s13058-019-1224-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a IHC analysis for COX-2 positive nuclei in tumors generated from control (Ctl) and shPTGS2 (KD2) DCIS.COM cells. Prism7 was utilized for statistical significance. Unpaired t test, *p value < 0.02. b IHC analysis for SIM2s positive nuclei in tumors generated from control (Ctl) and shPTGS2 (KD2) DCIS.com cells. Prism7 was utilized for statistical significance. Unpaired t test, *p value < 0.0001. c Correlation data for SIM2s and COX-2 positive nuclei in tumors generated from control and shPTGS2 DCIS.com cells. Prism7 was utilized for statistical significance. Unpaired t test, **p value < 0.01. d Images of IHC analysis for SIM2s in tumors generated from control and shPTGS2 DCIS.COM cells (left); DCIS.COM control, shPTGS2 (KD1), and shPTGS2 (KD2) were analyzed by western blot for SIM2s and GAPDH as loading control (right). e Pie Chart to show percent tumor progression DCIS+IDC or IDC only in the control group (n = 8) and shPTGS2 (n = 4). f SIM2s expression in SUM159 control cells and cells dosed with 20 μM celecoxib by qPCR as fold change. g SIM2s expression in DCIS.COM control cells and cells dosed with 50 μM DHA by qPCR as fold change. h SIM2s expression in MCF7 cells dosed with vehicle or 100 μM PGE2 for 24 h by qPCR, unpaired t test: p < 0.08. i SIM2s expression in DCIS.COM cells treated with vehicle (control) or 50 μM DHA by qPCR. Unpaired t test: *p < 0.05