Skip to main content
. 2019 Nov 20;14:833–842. doi: 10.1515/med-2019-0097

Figure 3.

Figure 3

Mechanism dissection of how circUCK2 can suppress the PCa cell growth: via increase TET1 expression. (A) After searching the literature and database, we found that miR-767-5p can interact with 3’-UTR of TET1. (B) West blotting shows that the expression of TET1 was decreased in EnzR-C4-2 cells. (C) West blotting shows that the level of TET1 was increased by overexpressing circUCK2, which can be reversed by overexpressing miR-767-5p in EnzR-C4-2 cells. (D-E) MTT assay shows that cell proliferation (D) and invasion (E) inhibition by overexpressing circUCK2 can be reversed by knocking down TET1 in EnzR-C4-2 cells. The data shown represent the mean of three independent experiments. *p < 0.05 by Student’s t-test for two groups or ANOVA for more than two groups.