Table 2.
The top 5 BP, CC, and MF enrichment analyses of the upregulated and downregulated DEGs.
| Ontology | GO ID | Description | Count | Gene ratio | P value | Adjust p value | FDR |
|---|---|---|---|---|---|---|---|
| Downregulated | |||||||
| BP | GO: 0030198 | Extracellular matrix organization | 18 | 0.22 | 9.33E-15 | 2.08E-11 | 1.57E-11 |
| BP | GO: 0043062 | Extracellular structure organization | 18 | 0.22 | 1.18E-13 | 1.31E-10 | 9.87E-11 |
| BP | GO: 0006027 | Glycosaminoglycan catabolic process | 8 | 0.10 | 3.29E-10 | 2.39E-07 | 1.80E-07 |
| BP | GO: 0006026 | Aminoglycan catabolic process | 8 | 0.10 | 4.29E-10 | 2.39E-07 | 1.80E-07 |
| BP | GO: 0042340 | Keratan sulfate catabolic process | 5 | 0.06 | 1.37E-09 | 4.85E-07 | 3.66E-07 |
| CC | GO: 0062023 | Collagen-containing extracellular matrix | 24 | 0.30 | 1.59E-21 | 2.83E-19 | 2.17E-19 |
| CC | GO: 0031012 | Extracellular matrix | 24 | 0.30 | 6.65E-20 | 5.92E-18 | 4.55E-18 |
| CC | GO: 0043202 | Lysosomal lumen | 10 | 0.13 | 6.91E-12 | 4.10E-10 | 3.15E-10 |
| CC | GO: 0005775 | Vacuolar lumen | 11 | 0.14 | 1.45E-10 | 6.43E-09 | 4.95E-09 |
| CC | GO: 0005796 | Golgi lumen | 8 | 0.10 | 1.13E-08 | 4.04E-07 | 3.10E-07 |
| MF | GO: 0005201 | Extracellular matrix structural constituent | 15 | 0.19 | 6.88E-16 | 1.64E-13 | 1.36E-13 |
| MF | GO: 0030021 | Extracellular matrix structural constituent conferring compression resistance | 5 | 0.06 | 3.94E-08 | 4.68E-06 | 3.89E-06 |
| MF | GO: 0019838 | Growth factor binding | 7 | 0.09 | 1.63E-06 | 0.000129 | 0.000107 |
| MF | GO: 0005518 | Collagen binding | 4 | 0.05 | 0.000195 | 0.011595 | 0.009641 |
| MF | GO: 0005539 | Glycosaminoglycan binding | 6 | 0.08 | 0.000353 | 0.016785 | 0.013956 |
| Upregulated | |||||||
| BP | GO: 0007565 | Female pregnancy | 8 | 0.14 | 1.43E-07 | 0.000172 | 0.000127 |
| BP | GO: 0045787 | Positive regulation of cell cycle | 10 | 0.18 | 2.06E-07 | 0.000172 | 0.000127 |
| BP | GO: 0044706 | Multi-multicellular organism process | 8 | 0.14 | 4.63E-07 | 0.000206 | 0.000151 |
| BP | GO: 0045931 | Positive regulation of mitotic cell cycle | 7 | 0.13 | 4.93E-07 | 0.000206 | 0.000151 |
| BP | GO: 0007059 | Chromosome segregation | 8 | 0.14 | 2.09E-06 | 0.000699 | 0.000513 |
| CC | GO: 0005819 | Spindle | 8 | 0.14 | 7.09E-06 | 0.001305 | 0.001105 |
| CC | GO: 0030496 | Midbody | 6 | 0.10 | 1.47E-05 | 0.001354 | 0.001146 |
| CC | GO: 0000922 | Spindle pole | 5 | 0.09 | 0.000108 | 0.006634 | 0.005617 |
| CC | GO: 0072686 | Mitotic spindle | 4 | 0.07 | 0.000234 | 0.009674 | 0.008191 |
| CC | GO: 0000777 | Condensed chromosome kinetochore | 4 | 0.07 | 0.000263 | 0.009674 | 0.008191 |
| MF | GO: 0044389 | Ubiquitin-like protein ligase binding | 6 | 0.12 | 0.000207 | 0.038328 | 0.031622 |