Table 5.
The top 10 significantly enriched reactome pathways of module 1 and 2.
| Reactome ID | Description | Count | P value | FDR | Gene symbol |
|---|---|---|---|---|---|
| Module 1 | |||||
| R-HSA-68886 | M Phase | 8 | 1.48E-09 | 4.09E-08 | CDK1, UBE2C, CCNB1, CCNB2, BIRC5, KIF20A, CENPN, CENPM |
| R-HSA-2500257 | Resolution of sister chromatid cohesion | 6 | 2.16E-09 | 4.09E-08 | CDK1, CCNB1, CCNB2, BIRC5, CENPN, CENPM |
| R-HSA-69620 | Cell cycle checkpoints | 7 | 7.98E-09 | 1.01E-07 | CDK1, UBE2C, CCNB1, CCNB2, BIRC5, CENPN, CENPM |
| R-HSA-68877 | Mitotic prometaphase | 6 | 3.48E-08 | 3.30E-07 | CDK1, CCNB1, CCNB2, BIRC5, CENPN, CENPM |
| R-HSA-2514853 | Condensation of prometaphase chromosomes | 3 | 1.81E-07 | 1.37E-06 | CDK1, CCNB1, CCNB2 |
| R-HSA-162658 | Golgi cisternae pericentriolar stack reorganization | 3 | 3.99E-07 | 2.52E-06 | CDK1, CCNB1, CCNB2 |
| R-HSA-6804114 | TP53 regulates transcription of genes involved in G2 cell cycle arrest | 3 | 8.91E-07 | 4.82E-06 | CDK1, CCNB1, AURKA |
| R-HSA-176412 | Phosphorylation of the APC/C | 3 | 1.06E-06 | 5.01E-06 | CDK1, UBE2C, CCNB1 |
| R-HSA-69275 | G2/M transition | 5 | 1.45E-06 | 5.61E-06 | CDK1, CCNB1, CCNB2, AURKA, TPX2 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5 | 1.53E-06 | 5.61E-06 | CDK1, CCNB1, CCNB2, AURKA, TPX2 |
| Module 2 | |||||
| R-HSA-2022857 | Keratan sulfate degradation | 3 | 5.73E-09 | 1.81E-08 | ACAN, FMOD, LUM |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 3 | 6.56E-08 | 1.04E-07 | ACAN, FMOD, LUM |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 3 | 1.20E-07 | 1.26E-07 | ACAN, FMOD, LUM |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 3 | 2.13E-07 | 1.68E-07 | ACAN, FMOD, LUM |
| R-HSA-1474244 | Extracellular matrix organization | 4 | 6.33E-07 | 4.00E-07 | ACAN, FMOD, MMP2, LUM |
| R-HSA-3000178 | ECM proteoglycans | 3 | 1.40E-06 | 7.38E-07 | ACAN, FMOD, LUM |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 3 | 6.16E-06 | 2.78E-06 | ACAN, FMOD, LUM |
| R-HSA-3781865 | Diseases of glycosylation | 3 | 9.47E-06 | 3.74E-06 | ACAN, FMOD, LUM |
| R-HSA-71387 | Metabolism of carbohydrates | 3 | 8.32E-05 | 2.92E-05 | ACAN, FMOD, LUM |
| R-HSA-1474228 | Degradation of the extracellular matrix | 2 | 0.001018 | 0.0003214 | ACAN, MMP2 |