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. 2019 Nov 26;12:10213–10225. doi: 10.2147/OTT.S211973

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© 2019 Ding et al.

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Src is the upstream kinase catalyzing Y228 phosphorylation of p120-catenin. (A) Representative immunohistochemical result of low Src expression in colon adenocarcinoma (IHC score=1). (B) Representative immunohistochemical result of high Src expression in colon adenocarcinoma (IHC score=4). (C) Higher Src expression is correlated with higher pY228-p120-catenin level in clinical CAC tissues (P=0.003). (D) Overexpression of Src induced hyperphosphorylation of Y228 on p120-catenin, while silencing Src by siRNA resulted in a lower pY228-p120-catenin level compared to the control group. (E) A schematic model shows our hypothesis that p120-catenin exhibits anticancer functions via E-cadherin and RhoA signaling pathways.