Table 4.

Comparison of alternative isoforms of selected brain or senescence genes in senescent and non-senescent astrocytes

	Early passage astrocytes	Late passage astrocytes	p value
GFAPΑ	0.809 (0.208)	0.062 (0.013)	0.0021
sKLOTHO	1.155 (0.209)	0.498 (0.275)	0.131
mKLOTHO	1.059 (0.122)	0.381 (0.012)	0.005
AQPM23	1.252 (0.459)	1.067 (0.434)	0.784
TAU3	1.044 (0.114)	0.603 (0.043)	0.023
TAU4	1.23 (0.674)	1.542 (0.196)	0.679
PSEN2	1.009 (0.12)	1.921 (0.158)	0.01
CDKN2A-p14ARF	1.043 (0.044)	0.532 (0.048)	0.001
CDKN2A-p16Ink4A	1.061 (0.076)	2.133 (0.127)	0.002
p21a	1.079 (0.085)	1.666 (0.087)	0.009
p21b	1.016 (0.095)	2.041 (0.077)	0.001
TP53	0.974 (0.052)	1.038 (0.082)	0.541
ATM	0.926 (0.097)	0.612 (0.069)	0.057

Values given refer to the mean expression of each splicing factor in either early or late passage cells. Values in parentheses are the standard error of the mean. Transcripts demonstrating significant differences in expression are given in boldface. N = 3 biological and 3 technical replicates per sample