| 3.1 Overall response ‐ assessable patients‐all trials |
46 |
9044 |
Risk Ratio (M‐H, Random, 95% CI) |
1.29 [1.14, 1.45] |
| 3.1.1 Question 1: Regimen A versus Regimen A + Other |
29 |
6102 |
Risk Ratio (M‐H, Random, 95% CI) |
1.37 [1.20, 1.56] |
| 3.1.2 Question 2: Regimen A versus Regimen C (poly) |
17 |
2942 |
Risk Ratio (M‐H, Random, 95% CI) |
1.13 [0.87, 1.47] |
| 3.2 Overall response ‐ assessable patients first line |
25 |
4767 |
Risk Ratio (M‐H, Random, 95% CI) |
1.35 [1.16, 1.56] |
| 3.2.1 Question 1: Regimen A versus Regimen A + other |
17 |
3055 |
Risk Ratio (M‐H, Random, 95% CI) |
1.38 [1.14, 1.66] |
| 3.2.2 Question 2: Regimen A versus Regimen C (poly) |
8 |
1712 |
Risk Ratio (M‐H, Random, 95% CI) |
1.31 [1.01, 1.69] |
| 3.3 Overall response ‐ Question 1 ‐ Regimen A versus A + other ‐ assessable patients |
27 |
5125 |
Risk Ratio (M‐H, Random, 95% CI) |
1.32 [1.16, 1.50] |
| 3.3.1 Sub group A: Single anthracycline agent versus anthracycline + other regimen |
16 |
3084 |
Risk Ratio (M‐H, Random, 95% CI) |
1.15 [1.02, 1.31] |
| 3.3.2 Sub group B: Single alkylating agent versus alkylanting agent + other |
5 |
390 |
Risk Ratio (M‐H, Random, 95% CI) |
1.60 [0.96, 2.67] |
| 3.3.3 Sub group C: Single antimetabolite versus antimetabolite + other |
3 |
275 |
Risk Ratio (M‐H, Random, 95% CI) |
2.95 [1.92, 4.52] |
| 3.3.4 Sub group D: Single taxane versus taxane + other |
3 |
1376 |
Risk Ratio (M‐H, Random, 95% CI) |
1.52 [1.26, 1.83] |
| 3.4 Overall response ‐ Question 2 ‐ Regimen A versus Regimen C ‐ assessable patients |
16 |
2713 |
Risk Ratio (M‐H, Random, 95% CI) |
1.11 [0.84, 1.48] |
| 3.4.1 Sub group E ‐ Single anthrycycline agent versus non‐anthrycycline combination regimen |
4 |
714 |
Risk Ratio (M‐H, Random, 95% CI) |
1.42 [1.15, 1.76] |
| 3.4.2 Sub group F ‐ Single taxane versus non‐taxane, non‐anthrycycline containing combination regimen |
5 |
1202 |
Risk Ratio (M‐H, Random, 95% CI) |
0.80 [0.48, 1.33] |
| 3.4.3 Sub group G ‐ Single non‐taxane, non‐anthrycycline agent versus other combination regimen |
7 |
797 |
Risk Ratio (M‐H, Random, 95% CI) |
1.28 [0.79, 2.08] |
| 3.5 Overall response ‐ single agent taxane versus all combinations |
8 |
2578 |
Risk Ratio (M‐H, Random, 95% CI) |
1.03 [0.72, 1.48] |
| 3.6 Overall response ‐ single agent anthracycline versus all combinations |
20 |
3798 |
Risk Ratio (M‐H, Random, 95% CI) |
1.19 [1.06, 1.34] |
