Table 2.

Comparison of anatomical brain volumes in sham WT and ATX mice measured by 7-T MRI

Normalized brain area volumes	WT (n = 11)	ATX (n = 12)	% of change	p value
Total brain	1.000 ± 0.000	1.000 ± 0.000	0.00	0.600
Amygdala	0.110 ± 0.003	0.112 ± 0.003	1.82	0.026
Cerebellum	0.410 ± 0.016	0.414 ± 0.009	0.98	0.559
Corpus callosum	0.097 ± 0.007	0.113 ± 0.004	16.49	< 0.0001
Cortex	0.982 ± 0.005	0.968 ± 0.004	− 1.43	< 0.0001
Deep gray matter	1.333 ± 0.054	1.332 ± 0.021	− 0.08	0.934
Entorhinal cortex	0.077 ± 0.002	0.072 ± 0.002	− 6.49	< 0.0001
Frontal cortex	0.301 ± 0.004	0.300 ± 0.005	− 0.33	0.621
Hippocampus	0.195 ± 0.004	0.190 ± 0.007	− 2.56	0.018
Occipital cortex	0.049 ± 0.002	0.046 ± 0.002	− 6.12	0.002
Olfactory bulb	0.245 ± 0.010	0.244 ± 0.004	− 0.41	0.621
Parietotemporal cortex	0.555 ± 0.007	0.549 ± 0.005	− 1.08	0.020
Septum	0.030 ± 0.001	0.029 ± 0.001	− 3.33	0.033
White matter	0.239 ± 0.011	0.246 ± 0.016	2.93	0.231

ATX mice were smaller than WT mice but brain weight-to-body weight ratio was identical in WT (0.012 ± 0.000 g/g) and ATX (0.012 ± 0.000 g/g) mice. Each volume from the brain region of interest was normalized to the total brain volume within the corresponding genotype to avoid bias in change in cerebral volume due to smaller body size. Data are mean ± SEM. p < 0.05 vs. WT mice