Table 4.
Expression of inflammatory, oxidative, senescence, apoptotic, and synaptic gene markers in the ipsilateral hemisphere parenchyma of WT and ATX mice
| WT (n = 12) | ATX (n = 12) | |||
|---|---|---|---|---|
| Sham (n = 6) | TAC (n = 6) | Sham (n = 6) | TAC (n = 6) | |
| Tnfα | 1.00 ± 0.02 | 1.54 ± 0.20 $ | 1.14 ± 0.02 | 1.62 ± 0.19 |
| Il1ß | 1.00 ± 0.09 | 1.72 ± 0.22 $ | 1.23 ± 0.11 | 1.50 ± 0.11 |
| Il6 | 1.00 ± 0.03 | 1.19 ± 0.14 | 1.43 ± 0.14 * | 0.78 ± 0.13 *,$ |
| Gfap | 1.00 ± 0.11 | 1.31 ± 0.10 | 1.54 ± 0.07 * | 1.65 ± 0.06 |
| Sod2 | 1.00 ± 0.12 | 0.89 ± 0.08 | 0.81 ± 0.12 | 0.58 ± 0.07 * |
| Nox2 | 1.00 ± 0.07 | 1.59 ± 0.11 $ | 1.30 ± 0.06 * | 1.68 ± 0.09 $ |
| Nox4 | 1.00 ± 0.08 | 1.81 ± 0.32 $ | 1.52 ± 0.21 | 1.43 ± 0.06 |
| p21 | 1.00 ± 0.01 | 1.35 ± 0.12 $ | 1.19 ± 0.06 | 1.37 ± 0.10 |
| p16 | 1.00 ± 0.07 | 1.47 ± 0.17 $ | 1.01 ± 0.15 | 0.55 ± 0.13 *,$ |
| Bcl2 | 1.00 ± 0.20 | 0.80 ± 0.18 | 0.71 ± 0.14 | 0.93 ± 0.21 |
| Bax | 1.00 ± 0.10 | 1.04 ± 0.14 | 0.93 ± 0.17 | 0.94 ± 0.10 |
| Bax/Bcl2 | 1.00 ± 0.21 | 1.23 ± 0.19 | 1.09 ± 0.17 | 0.92 ± 0.19 |
| Syp | 1.00 ± 0.05 | 0.69 ± 0.07 $ | 0.64 ± 0.11 * | 0.50 ± 0.03 |
| Psd-95 | 1.00 ± 0.12 | 1.15 ± 0.21 | 1.22 ± 0.03 | 0.63 ± 0.14 *,$ |
| NeuN | 1.00 ± 0.04 | 0.79 ± 0.06 | 0.78 ± 0.11 | 0.81 ± 0.12 |
| Bdnf | 1.00 ± 0.07 | 0.83 ± 0.07 | 0.67 ± 0.04 * | 0.62 ± 0.10 |
Data are mean ± SEM. *p < 0.05 vs. WT; $p < 0.05 vs. sham (within the corresponding genotype)