Skip to main content
. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Matrix Biol. 2019 Jun 1;85-86:94–111. doi: 10.1016/j.matbio.2019.05.006

Fig. 1. Protease-dependent and -independent cancer cell invasion of covalently cross-linked basement membranes.

Fig. 1

Schematic depicting basement membrane invasion, including (top) protease-dependent modes and (bottom) a protease-independent mode, recently shown, that is mediated by extracellular matrix mechanical plasticity combined with cell-generated forces [20]. The role of covalent cross-linking in mediating the second mode of invasion remains unclear.