Figure 7.

Patient 5 papillomatous conjunctival tumor

A) Slit lamp photo of a papillary OSSN from patient 5. B) HR-OCT image of tumor margin denoted by white arrow. C) Slit lamp photo reference landmark (red star), a Y bifurcation of a conjunctival vessel. D) OCT en-face reconstruction of ocular surface with reference landmark denoted by red star. Internal calipers used to measure the distance from the predicted tumor margin (white x) to the reference landmark. F) Examination of the excised conjunctiva discloses faulty epithelial maturational sequencing that extends up to full thickness in a variable papillary configuration (carcinoma in situ, papillary) with the area of predicted tumor margin (orange pigment, arrow) adjacent to the transition of unremarkable and thickened, dysplastic epithelium (asterisk) (Hematoxylineosin; original magnification x200).