Figure 9.

Patient 8 elevated conjunctival tumor

A) Slit lamp photo of limbal OSSN lesion from patient 8. B) HR-OCT image indicates tumor margin denoted by white arrow. C) Slit lamp photo of limbal OSSN lesion with reference landmark D) OCT en-face reconstruction of ocular surface with reference landmark denoted by red star and measurement of temporal tumor margin. Of note, the HR-OCT predicted tumor margin (white x) was temporal to the obvious discreet tumor seen (dashed white lines) E) Examination of the excised conjunctiva discloses faulty epithelial maturational sequencing that extends up to full thickness (carcinoma in situ) with the area of predicted tumor margin (arrow, orange pigment) adjacent to the transition of unremarkable and dysplastic epithelium (asterisk) (Hematoxylin-eosin; original magnification x200).