Table 2. Effect of 1,25(OH)2D3 on gene expression in CK pNK and uNK.
Summary of total genes differentially induced or suppressed by 1,25(OH)2D3 in CK-stimulated pNK and CK-stimulated uNK (fold change < −1.5 or > +1.5, p ≤ 0.05), with sub-categorisation according to transcript function.
| Functional classification | Genes expressed in pNK |
Genes expressed in uNK |
||||
|---|---|---|---|---|---|---|
| Total transcripts | Up-regulated by 1,25(OH)2D3 | Down-regulated by 1,25(OH)2D3 | Total transcripts | Up-regulated by 1,25(OH)2D3 | Down-regulated by 1,25(OH)2D3 | |
| Cell structure | 3 | TTLL1, FAM161A | CMYA5 | 2 | CAMSAP2, SOBP | |
| Cell survival, proliferation, invasion, adhesion, angiogenesis, trafficking | 15 | TMEM14A, MMP14, PIK3R6, ENG, RABL2A, DEPDC1B, TRIM35, CAB39L, AP5S1 | TSPAN4, SERPINI1, NRP2, RAPGEFL1, FAM195A, AP4M1 | 27 | TSPAN2, ARAP3, ITGAM,RARRES3, ADGRE5, FGL2, DYSF, NINI1, ZFP91-CNTF, DENND6B, BGLAP, DOCK3, RNF165, TAX1BP3, TRIM35, TAGLN2, RGS3 | ADGRG1, TMPRSS6, CYGB, C8orf44-SGK3, LZTS3, MARCKSL1, NACAD, TCF7L2, PHOSPHO2-KLH23, P2RY11 |
| Immune function | 3 | LXN, MTCP1, RSAD2 | 4 | SERPINB1, LGALS9, RELT | RSAD2 | |
| Metabolism and lipogenesis | 17 | ACOT1, ACSF2, CCBL1, MTHFD2L, PPP1R3F, AMPD3, GRHPR | PM20D2, TKFC, KDELC1, BDH2, GMPR, BCKDHB, NBR2, NPR2, ENPP1, NR2F6 | 7 | TMEM56-RWDD3, SARDH, CYP1A1, GDPGP1, ACSL1, GDE1, ADA | |
| Genetic | 10 | CBX8, DNAJC30, RPA3, EXOSC7, PPFIBP1 | TUT1, GTPBP3, MIR600HG, TCEANC, TYRO3P | 9 | TFEC, WWC2, ZBTB7A, HIC1, EFL1, HNRNPLL,TRAK1, CREG1 | BHLHB9 |
| Ion transport | 1 | SLC35E3 | 2 | SLC31A1 | SLC22A1 | |
| Unknown function | 10 | LOC101929767, TTC32, LOC100287042, PROB1 | ARMCX4, LOC441666, LOC100506804, PRRG4, CBWD6, THAP8 | 8 | ZSWIM5, LOC101928464, TNRC6C-AS1, POMGNT2, PLEKho2, NARS2, INTS6L | C1QTNF3-AMACR |
| Anti-sense, non-coding, snoRNAs | 11 | BRWD1-IT2, SNORA67, SNORA17B, LOC100129083, ADNP-AS1, RPL13P5 | C22orf34, SNHG25, TRIM47, MRPL42P5, GCSHP3 | 6 | SNORA17A, SIGLEC17P, NPPA-As1 | CCDC102A, ALMS1-ITI, LOC100505771 |