Figure 2. Body mass and glucose homeostasis of the EC Adk-deficient mice on a chow diet (CD).

A. Body weight of Adk^WT and Adk^ΔVEC mice at the indicated age (n = 9–10 mice per group). B. Lean and fat content of Adk^WT and Adk^ΔVEC mice at the age of 14 weeks (n = 8 mice per group). C. The weight of epididymal WAT (eWAT) in Adk^WT and Adk^ΔVEC mice at the age of 14 weeks (n = 15–17 mice per group). D. Fasting blood glucose levels of Adk^WT and Adk^ΔVEC mice at the age of 14 weeks (n = 7–13 mice per group). E. Blood glucose levels (left) and AUC (area under the curve, right) during GTT (glucose tolerance test) in Adk^WT and Adk^ΔVEC mice at the age of 16 weeks (n = 6 mice per group). Mice were fasted for 6 h and injected with glucose (2 g/kg i.p.). F. Blood glucose levels (left) and AAC (area above the curve, right) during ITT (insulin tolerance test) in Adk^WT and Adk^ΔVEC mice at the age of 17 weeks (n = 5–6 mice per group). Mice were fasted for 4 h and injected with insulin (1 unit/kg i.p.). All data are represented as mean ± SEM, *P < 0.05 and **P < 0.01 for Adk^ΔVEC vs. Adk^WT (unpaired two-tailed Student’s t test).