Table 3:
Genetic risk score (GRS) of lipid traits and risk of large-for-gestational age (LGA) and small-for-gestational age (SGA) stratified by offspring sex (N=2,008 from the NICHD Fetal Growth Studies – Singleton cohort).
| Risk of LGA | Risk of SGA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Boys only | Girls only | Boys only | Girls only | |||||||||
| N | OR | (95% CI) | N | OR | (95% CI) | N | OR | (95% CI) | N | OR | (95% CI) | |
| Whites | ||||||||||||
| GRSTChol | 293 | 1.06 | (0.99 to 1.13) | 255 | 0.92 | (0.86 to 0.98) | 225 | 0.96 | (0.88 to 1.05) | 225 | 0.92 | (0.83 to 1.03) |
| GRSHDLc | 293 | 0.99 | (0.93 to 1.05) | 255 | 1.03 | (0.97 to 1.09) | 225 | 1.02 | (0.93 to 1.12) | 225 | 0.99 | (0.90 to 1.09) |
| GRSLDLc | 293 | 1.04 | (0.97 to 1.12) | 255 | 1.00 | (0.92 to 1.08) | 225 | 1.00 | (0.90 to 1.11) | 225 | 0.88 | (0.77 to 1.00) |
| GRSTG | 293 | 1.09 | (1.02 to 1.17) | 255 | 0.99 | (0.92 to 1.06) | 225 | 0.95 | (0.86 to 1.06) | 225 | 0.93 | (0.82 to 1.06) |
| Blacks | ||||||||||||
| GRSTChol | 221 | 1.04 | (0.93 to 1.16) | 224 | 0.94 | (0.82 to 1.06) | 258 | 1.07 | (0.99 to 1.16) | 272 | 0.97 | (0.90 to 1.04) |
| GRSHDLc | 221 | 0.99 | (0.90 to 1.10) | 224 | 1.09 | (0.97 to 1.23) | 258 | 1.00 | (0.93 to 1.07) | 272 | 0.99 | (0.92 to 1.06) |
| GRSLDLc | 221 | 1.05 | (0.92 to 1.20) | 224 | 0.90 | (0.79 to 1.03) | 258 | 1.08 | (0.98 to 1.18) | 272 | 0.99 | (0.91 to 1.08) |
| GRSTG | 221 | 0.96 | (0.85 to 1.10) | 224 | 1.15 | (0.97 to 1.37) | 258 | 0.97 | (0.89 to 1.07) | 272 | 0.95 | (0.87 to 1.04) |
| Hispanics | ||||||||||||
| GRSTChol | 235 | 0.99 | (0.91 to 1.09) | 232 | 1.02 | (0.93 to 1.12) | 208 | 0.98 | (0.91 to 1.06) | 214 | 1.05 | (0.96 to 1.15) |
| GRSHDLc | 235 | 0.98 | (0.90 to 1.07) | 232 | 1.02 | (0.93 to 1.13) | 208 | 1.02 | (0.95 to 1.10) | 214 | 1.02 | (0.95 to 1.11) |
| GRSLDLc | 235 | 0.99 | (0.88 to 1.11) | 232 | 1.03 | (0.91 to 1.16) | 208 | 1.02 | (0.93 to 1.12) | 214 | 1.02 | (0.93 to 1.12) |
| GRSTG | 235 | 1.00 | (0.89 to 1.11) | 232 | 1.02 | (0.90 to 1.15) | 208 | 0.93 | (0.85 to 1.02) | 214 | 1.07 | (0.98 to 1.18) |
| Asians | ||||||||||||
| GRSTChol | 70 | 0.88 | (0.70 to 1.12) | 61 | 1.06 | (0.86 to 1.31) | 70 | 0.89 | (0.69 to 1.13) | 92 | 1.06 | (0.95 to 1.19) |
| GRSHDLc | 70 | 1.41 | (0.93 to 2.14) | 61 | 1.24 | (0.92 to 1.67) | 70 | 1.07 | (0.88 to 1.31) | 92 | 1.02 | (0.90 to 1.16) |
| GRSLDLc | 70 | 1.06 | (0.81 to 1.39) | 61 | 1.25 | (0.93 to 1.67) | 70 | 0.97 | (0.77 to 1.22) | 92 | 1.06 | (0.90 to 1.24) |
| GRSTG | 70 | 0.95 | (0.66 to 1.36) | 61 | 0.95 | (0.79 to 1.15) | 70 | 0.90 | (0.71 to 1.13) | 92 | 1.02 | (0.90 to 1.15) |
Adjusted for maternal age, pre-pregnancy BMI, highest level of education, marital status, parity, diabetes, pregnancy-related hypertensive diseases and for the first five genetic principal components